Structure of PDB 6g1s Chain A

Receptor sequence

>6g1sA (length=645) Species: 10090 (Mus musculus)

RPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQASESGK
VIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVVKSYD
VIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVYNNIM
RRYLKQKLRNNDLKAIPLPQILGLTASPGVGAAKKQSEAEKHILNICANL
DAFTIKTVKENLGQLKHQIKEPCKKFVIANPFKEKLLEIMASIQTYCQKS
PMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHLRKYNEALQINDTIR
MIDAYSHLETFYTDEKEKKFAVLNDETDEFLMNLFFDNKKMLKKLAENPK
EKLIKLRNTILEQFTRSSRGIIFTKTRQSTYALSQWIMENAKVKAHHLIG
AGHSSEVKPMTQTEQKEVISKFRTINLLIATTVAGLDIKECNIVIRYGLV
TNEIAMVQARGRARADESTYVLVTSSGVTEREIVNDFREKMMYKAINRVQ
NMKPEEYAHKILELQVQSILEKKMKVKRSIAKQYNDNPSLITLLCKNCSM
LVCSGENIHVIEKMHHVNMTPEFKGLYIVRENKTNGEIICKCGQAWGTMM
VHKGLDLPCLKIRNFVVNFSPKKQYKKWVELPIRFPDLDYSEYCL

3D structure

• PDB: 6g1s Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
• Chain: A
• Resolution: 3.93 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	K451 A453 H578 Q581 T767 T769 N812 H927	K142 A144 H259 Q262 T411 T413 N452 H565
BS02	rna	A	N365 K366 V367 G393 Q416 E580 Q581 K726 T727 R728 I755 G756 A757 S761 T789 T790 V791 E924 M926 K975	N56 K57 V58 G84 Q107 E261 Q262 K375 T376 R377 I399 G400 A401 S405 T431 T432 V433 E562 M564 K603
BS03	ZN	A	C910 C964	C548 C592

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0005524 ATP binding

External links

• PDB: RCSB:6g1s, PDBe:6g1s, PDBj:6g1s
• PDBsum: 6g1s
• PubMed: 30449722
• UniProt: Q8R5F7|IFIH1_MOUSE Interferon-induced helicase C domain-containing protein 1 (Gene Name=Ifih1)