Structure of PDB 6g0w Chain A

Receptor sequence
>6g0wA (length=185) Species: 9606 (Homo sapiens) [Search protein sequence]
KQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQA
KKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRAGKNAVGKGTYFA
VNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNP
TDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK
3D structure
PDB6g0w Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14.
ChainA
Resolution2.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EGW A H1682 G1683 A1706 Y1714 S1722 Y1727 H1753 D1775 L1782 H70 G71 A92 Y98 S106 Y111 H137 D159 L166 MOAD: ic50=5.2uM
PDBbind-CN: -logKd/Ki=5.28,IC50=5.2uM
BindingDB: IC50=5248nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6g0w, PDBe:6g0w, PDBj:6g0w
PDBsum6g0w
PubMed29748053
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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