Structure of PDB 6g07 Chain A

Receptor sequence
>6g07A (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
YASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSM
WEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLV
RMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFS
EDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLSKTHRQSIL
AKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFST
3D structure
PDB6g07 Optimizing a Weakly Binding Fragment into a Potent ROR gamma t Inverse Agonist with Efficacy in an in Vivo Inflammation Model.
ChainA
Resolution1.66 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K336 Q346 Q349 I350 P500 L501 E504 K73 Q83 Q86 I87 P237 L238 E241
BS02 peptide A I492 Q495 I229 Q232
BS03 EEZ A Q286 L287 C320 R364 M365 R367 A368 F377 F378 F388 I400 Q23 L24 C57 R101 M102 R104 A105 F114 F115 F125 I137 MOAD: Kd=35.5nM
PDBbind-CN: -logKd/Ki=4.57,IC50=27uM
BindingDB: IC50=255nM,Kd=36nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6g07, PDBe:6g07, PDBj:6g07
PDBsum6g07
PubMed29990434
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

[Back to BioLiP]