Structure of PDB 6fzx Chain A

Receptor sequence
>6fzxA (length=298) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
AEAGGPGGNQKIGKYTYGSDYGPLIVNDRCEMDDGNVITVDMNSSTDDSK
TTPFRFACPTNTYKQVNGAYSPLNDAHFFGGVVFKLYRDWFGTSPLTHKL
YMKVHYGRSVENAYWDGTAMLFGDGATMFYPLVSLDVAAHEVSHGFTEQN
SGLIYRGQSGGMNEAFSDMAGEAAEFYMRGKNDFLIGYDIKKGSGALRYM
DQPSRDGRSIDNASQYYNGIDVHHSSGVYNRAFYLLANSPGWDTRKAFEV
FVDANRYYWTATSNYNSGACGVIRSAQNRNYSAADVTRAFSTVGVTCP
3D structure
PDB6fzx Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H140 E141 H144 Y155 E164 D221 H223
Catalytic site (residue number reindexed from 1) H140 E141 H144 Y155 E164 D221 H223
Enzyme Commision number 3.4.24.26: pseudolysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EEK A N112 A113 H140 E141 H144 E164 D221 H223 H224 N112 A113 H140 E141 H144 E164 D221 H223 H224 MOAD: Ki=12.3uM
PDBbind-CN: -logKd/Ki=8.15,IC50=7.0nM
BS02 ZN A H140 H144 E164 H140 H144 E164
BS03 CA A D136 E172 E175 D183 L185 D136 E172 E175 D183 L185
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6fzx, PDBe:6fzx, PDBj:6fzx
PDBsum6fzx
PubMed30088919
UniProtP14756|ELAS_PSEAE Elastase (Gene Name=lasB)

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