Structure of PDB 6fzm Chain A

Receptor sequence
>6fzmA (length=190) Species: 9606 (Homo sapiens) [Search protein sequence]
MKQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQ
AKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGK
GTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSK
NPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK
3D structure
PDB6fzm A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity.
ChainA
Resolution2.67 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EE5 A H1682 G1683 K1704 N1705 Y1714 Y1721 S1722 T1726 Y1727 L1782 H71 G72 K93 N94 Y103 Y110 S111 T115 Y116 L171 PDBbind-CN: -logKd/Ki=6.04,IC50=0.917uM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6fzm, PDBe:6fzm, PDBj:6fzm
PDBsum6fzm
PubMed30344052
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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