Structure of PDB 6fzj Chain A

Receptor sequence
>6fzjA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
ADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDINSLMMG
EDKIKFKHITPEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLD
LNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQ
DNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTE
TDMSLHPLLQEIYKDLY
3D structure
PDB6fzj Recurrent activating mutations of PPAR gamma associated with luminal bladder tumors.
ChainA
Resolution2.011 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K329 L339 N340 Q342 V343 L346 L496 E499 K91 L101 N102 Q104 V105 L108 L258 E261
BS02 EDK A F310 C313 Q314 S317 H351 L358 I369 M376 F391 M392 H477 L497 Y501 F72 C75 Q76 S79 H113 L120 I131 M138 F153 M154 H239 L259 Y263 BindingDB: Ki=1.4nM,EC50=6.2nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fzj, PDBe:6fzj, PDBj:6fzj
PDBsum6fzj
PubMed30651555
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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