Structure of PDB 6fzg Chain A

Receptor sequence
>6fzgA (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
MQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYD
MNSLMMGEDKMKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAK
SIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTRE
FLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLL
NVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQ
LLQVIKKTETDMSLHPLLQEIYKDLY
3D structure
PDB6fzg Recurrent activating mutations of PPAR gamma associated with luminal bladder tumors.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EDK A F310 G312 C313 Q314 S317 H351 I369 F388 F391 H477 L493 L497 Y501 F81 G83 C84 Q85 S88 H122 I140 F159 F162 H248 L264 L268 Y272 PDBbind-CN: -logKd/Ki=6.55,Kd=0.28uM
BindingDB: Ki=1.4nM,EC50=6.2nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:6fzg, PDBe:6fzg, PDBj:6fzg
PDBsum6fzg
PubMed30651555
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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