Structure of PDB 6fzf Chain A

Receptor sequence
>6fzfA (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGF
VNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSL
RKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPI
EDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVMEHVQLLQVI
KKTETDMSLHPLLQEIYKDLY
3D structure
PDB6fzf Recurrent activating mutations of PPAR gamma associated with luminal bladder tumors.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E326 K329 L339 N340 Q342 V343 L346 P495 L496 E499 E92 K95 L105 N106 Q108 V109 L112 P261 L262 E265
BS02 EDK A I309 F310 G312 C313 Q314 S317 H351 Y355 L358 I369 M376 F391 M392 H477 L497 Y501 I75 F76 G78 C79 Q80 S83 H117 Y121 L124 I135 M142 F157 M158 H243 L263 Y267 BindingDB: Ki=1.4nM,EC50=6.2nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:6fzf, PDBe:6fzf, PDBj:6fzf
PDBsum6fzf
PubMed30651555
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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