Structure of PDB 6fyq Chain A

Receptor sequence
>6fyqA (length=443) Species: 1473 (Virgibacillus pantothenticus) [Search protein sequence]
RSLTELDKKHFIHPFSSIQEQQHKGAKVIMKEGDGIYLTDVTGKTYIDGV
SSLWNVNVGHGRVELAEAAAQQMKKMAFSSAFSTFSHEPAIRLAEKIASI
TPEGLNAVFFTSGGSESNDSAVKLVRHYWKIQGKPNKRKIISLKRSYHGV
AAASTSVTGIPEFWGMAGHMMTDFLHVDTHYNNTTEQAVQSLCQAIEEAG
PETIAAFFAEPVQGAGGVIIPPEDYFLRIREVCNAYGILFVADEVITGFG
RTGKMFGIENWDVIPDVMTFAKGVTSGYFPLGGVVVSDPIHEVLKEKSVG
TLFHGFTYSGHPTAAAVALKNIAIIKEERLVENSKRMGDALLHGLKKVKN
RLEIVGDVRFVGLLGAVELMQNPATNKPFSSNLQVAPKVIEALHELGVIC
RSVTYDHTNIICLAPPLIINQKQVDKLVEVIYEAILKVQQQLG
3D structure
PDB6fyq Strategic single point mutation yields a solvent- and salt-stable transaminase from Virgibacillus sp. in soluble form.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F16 Y148 D244 K273
Catalytic site (residue number reindexed from 1) F15 Y147 D243 K272
Enzyme Commision number 2.6.1.18: beta-alanine--pyruvate transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A G115 S116 Y148 H149 G150 E211 D244 V246 I247 K273 G114 S115 Y147 H148 G149 E210 D243 V245 I246 K272
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008483 transaminase activity
GO:0016223 beta-alanine:pyruvate transaminase activity
GO:0030170 pyridoxal phosphate binding

View graph for
Molecular Function
External links
PDB RCSB:6fyq, PDBe:6fyq, PDBj:6fyq
PDBsum6fyq
PubMed30401905
UniProtA0A4P1LYG1

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