Structure of PDB 6fyp Chain A

Receptor sequence
>6fypA (length=348) Species: 9606 (Homo sapiens) [Search protein sequence]
SVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVA
LKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCI
AFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDL
KPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTI
VATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLV
MMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSY
MLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSF
3D structure
PDB6fyp X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan-McDermid Syndrome.
ChainA
Resolution2.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3NG A L162 G163 E164 F167 V170 A184 K186 V220 F236 L239 N242 L290 D320 L28 G29 E30 F33 V36 A50 K52 V86 F102 L105 N108 L156 D186 MOAD: ic50=143nM
PDBbind-CN: -logKd/Ki=6.84,IC50=143nM
BindingDB: IC50=41nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6fyp, PDBe:6fyp, PDBj:6fyp
PDBsum6fyp
PubMed29985556
UniProtP49761|CLK3_HUMAN Dual specificity protein kinase CLK3 (Gene Name=CLK3)

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