Structure of PDB 6fyh Chain A

Receptor sequence

>6fyhA (length=115) Species: 9606 (Homo sapiens) [Search protein sequence]

PTIDIDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTS
KVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFE
KLRHMLLLAIQENSE

3D structure

PDB

6fyh beta-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation.

Chain

Resolution

2.906 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H350 C352
Catalytic site (residue number reindexed from 1)	H85 C87
Enzyme Commision number	2.3.2.26: HECT-type E3 ubiquitin transferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	H350 D357	H85 D92

Gene Ontology

	Molecular Function
GO:0004842	ubiquitin-protein transferase activity

External links

PDB	RCSB:6fyh, PDBe:6fyh, PDBj:6fyh
PDBsum	6fyh
PubMed	29964046
UniProt	Q7Z6Z7\|HUWE1_HUMAN E3 ubiquitin-protein ligase HUWE1 (Gene Name=HUWE1)