Structure of PDB 6fv2 Chain A

Receptor sequence
>6fv2A (length=301) Species: 277944 (Human coronavirus NL63) [Search protein sequence]
SGLKKMAQPSGCVERCVVRVCYGSTVLNGVWLGDTVTCPRHVIAPSTTVL
IDYDHAYSTMRLHNFSVSHNGVFLGVVGVTMHGSVLRIKVSQSNVHTPKH
VFKTLKPGDSFNILACYEGIASGVFGVNLRTNFTIKGSFINGACGSPGYN
VRNDGTVEFCYLHQIELGSGAHVGSDFTGSVYGNFDDQPSLQVESANLML
SDNVVAFLYAALLNGCRWWLCSTRVNVDGFNEWAMANGYTSVSSVECYSI
LAAKTGVSVEQLLASIQHLHEGFGGKNILGYSSLCDEFTLAEVVKQMYGV
N
3D structure
PDB6fv2 Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication Structure-based design, synthesis, and activity assessment.
ChainA
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D03 A V26 H41 I51 F139 N141 G142 A143 C144 H163 E166 D187 Q188 S190 V26 H41 I51 F139 N141 G142 A143 C144 H163 E166 D187 Q188 S190 PDBbind-CN: -logKd/Ki=4.30,IC50>50uM
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:6fv2, PDBe:6fv2, PDBj:6fv2
PDBsum6fv2
PubMed32045235
UniProtP0C6X5|R1AB_CVHNL Replicase polyprotein 1ab (Gene Name=rep)

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