Structure of PDB 6ful Chain A

Receptor sequence
>6fulA (length=478) Species: 9606 (Homo sapiens) [Search protein sequence]
SVSIYPSSAEVLKACRNLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPT
PSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLV
EANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQA
SSFQESLREEPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGN
LLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWF
VVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDL
VWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQSVKSI
VPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEI
IWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSG
NLENFVVLEQYKMEDLMQVYDQFTLAPP
3D structure
PDB6ful In Silico Identification of JMJD3 Demethylase Inhibitors.
ChainA
Resolution1.649 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E7Z A Y1135 K1137 T1143 H1146 N1156 H1226 V1228 Y218 K220 T226 H229 N239 H309 V311 PDBbind-CN: -logKd/Ki=4.92,IC50=12uM
BS02 MN A H1146 E1148 H1226 H229 E231 H309
BS03 ZN A C1331 C1334 C1358 C1361 C414 C417 C441 C444
External links
PDB RCSB:6ful, PDBe:6ful, PDBj:6ful
PDBsum6ful
PubMed30226987
UniProtO15550|KDM6A_HUMAN Lysine-specific demethylase 6A (Gene Name=KDM6A)

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