Structure of PDB 6fuk Chain A

Receptor sequence
>6fukA (length=477) Species: 9606 (Homo sapiens) [Search protein sequence]
SVSIYPSSAEVLKACRNLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPT
PSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLV
EANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQA
SSFQESLREPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNL
LSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFV
VPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLV
WINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQSVKSIV
PMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEII
WHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGN
LENFVVLEQYKMEDLMQVYDQFTLAPP
3D structure
PDB6fuk In Silico Identification of JMJD3 Demethylase Inhibitors.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H1146 E1148 H228 E230
BS02 8XQ A Y1135 K1137 T1143 H1146 N1156 W1166 H1226 Y217 K219 T225 H228 N238 W248 H308
BS03 ZN A C1331 C1334 C1358 C1361 C413 C416 C440 C443
External links
PDB RCSB:6fuk, PDBe:6fuk, PDBj:6fuk
PDBsum6fuk
PubMed30226987
UniProtO15550|KDM6A_HUMAN Lysine-specific demethylase 6A (Gene Name=KDM6A)

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