Structure of PDB 6fu5 Chain A

Receptor sequence
>6fu5A (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLTPLLD
SERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELL
HRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNE
FHVKIADFGLGTIIYMPPENYEPSIKHDIYSYAVITWEVLSRKQPFEDVT
NPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSF
LKCLIELEPVLRTFEEITFLEAVIQLKKTKLQ
3D structure
PDB6fu5 Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.
ChainA
Resolution3.26 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D146 Q150 N151 D164
Catalytic site (residue number reindexed from 1) D139 Q143 N144 D157
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E7N A L24 V32 A45 K47 L79 T95 M98 G101 E105 L153 D164 L20 V28 A41 K43 L72 T88 M91 G94 E98 L146 D157 PDBbind-CN: -logKd/Ki=7.50,IC50=31.6nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6fu5, PDBe:6fu5, PDBj:6fu5
PDBsum6fu5
PubMed30026309
UniProtO43353|RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (Gene Name=RIPK2)

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