Structure of PDB 6ft7 Chain A

Receptor sequence
>6ft7A (length=356) Species: 9606 (Homo sapiens) [Search protein sequence]
SKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHAR
GKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNF
HGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQ
LTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDH
EHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHE
NREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENC
KPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPE
ERSFHT
3D structure
PDB6ft7 Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.
ChainA
Resolution2.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E6Q A G163 E164 V170 A184 F236 L239 L290 G35 E36 V42 A56 F108 L111 L162 PDBbind-CN: -logKd/Ki=5.00,IC50>10uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6ft7, PDBe:6ft7, PDBj:6ft7
PDBsum6ft7
PubMed29723265
UniProtP49761|CLK3_HUMAN Dual specificity protein kinase CLK3 (Gene Name=CLK3)

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