Structure of PDB 6ft3 Chain A

Receptor sequence
>6ft3A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB6ft3 BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.
ChainA
Resolution1.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E5T A W81 P82 V87 L92 N140 I146 W40 P41 V46 L51 N99 I105 PDBbind-CN: -logKd/Ki=6.42,IC50=0.377uM
BindingDB: IC50=377nM
External links
PDB RCSB:6ft3, PDBe:6ft3, PDBj:6ft3
PDBsum6ft3
PubMed29776834
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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