Structure of PDB 6fsy Chain A

Receptor sequence
>6fsyA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB6fsy BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.
ChainA
Resolution1.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E5Q A W81 P82 F83 L92 N140 M149 W40 P41 F42 L51 N99 M108 PDBbind-CN: -logKd/Ki=6.61,Kd=0.247uM
BindingDB: IC50=166nM,Kd=247nM
External links
PDB RCSB:6fsy, PDBe:6fsy, PDBj:6fsy
PDBsum6fsy
PubMed29776834
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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