Structure of PDB 6fs2 Chain A

Receptor sequence
>6fs2A (length=152) Species: 9606 (Homo sapiens) [Search protein sequence]
DDLYRQSLEIISRYLREQATGSKDPLGEAGAAGRRALETLRRVGDGVQRN
HETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAF
VAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVED
LE
3D structure
PDB6fs2 Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E4K A M231 V249 H252 V253 M58 V76 H79 V80
BS02 E4K A H224 A227 F228 L235 V249 M250 R263 T266 L267 F270 G271 H51 A54 F55 L62 V76 M77 R90 T93 L94 F97 G98
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:6fs2, PDBe:6fs2, PDBj:6fs2
PDBsum6fs2
PubMed30559424
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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