Structure of PDB 6fs0 Chain A

Receptor sequence
>6fs0A (length=156) Species: 9606 (Homo sapiens) [Search protein sequence]
GPLGSEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRR
VGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIV
TLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGF
VEFFHV
3D structure
PDB6fs0 Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E4W A A227 M231 L235 V249 V253 R263 T266 L267 F270 G271 I294 A62 M66 L70 V84 V88 R98 T101 L102 F105 G106 I129 MOAD: Kd=0.00017uM
PDBbind-CN: -logKd/Ki=9.77,Kd=0.00017uM
BindingDB: IC50=<3.00nM,Ki=0.200000nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:6fs0, PDBe:6fs0, PDBj:6fs0
PDBsum6fs0
PubMed30559424
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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