Structure of PDB 6frf Chain A

Receptor sequence
>6frfA (length=118) Species: 9606 (Homo sapiens) [Search protein sequence]
MRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIV
KNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCS
KLAEVFEQEIDPVMQSLG
3D structure
PDB6frf Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E3T A P1110 Q1113 V1115 L1120 N1168 R1173 V1174 P31 Q34 V36 L41 N89 R94 V95 MOAD: ic50=0.04uM
PDBbind-CN: -logKd/Ki=7.40,IC50=0.040uM
BindingDB: IC50=40nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6frf, PDBe:6frf, PDBj:6frf
PDBsum6frf
PubMed30258543
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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