Structure of PDB 6fqq Chain A

Receptor sequence
>6fqqA (length=60) Species: 9606 (Homo sapiens) [Search protein sequence]
NLPKESVQILRDWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINAR
RRLLPDMLRK
3D structure
PDB6fqq TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling.
ChainA
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A L171 Q210 N217 R221 L2 Q41 N48 R52 PDBbind-CN: Kd=388.6nM
BS02 dna A Y191 K197 R219 R220 Y22 K28 R50 R51 PDBbind-CN: Kd=388.6nM
Gene Ontology
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6fqq, PDBe:6fqq, PDBj:6fqq
PDBsum6fqq
PubMed30060237
UniProtQ15583|TGIF1_HUMAN Homeobox protein TGIF1 (Gene Name=TGIF1)

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