Structure of PDB 6fqp Chain A

Receptor sequence
>6fqpA (length=67) Species: 9606 (Homo sapiens) [Search protein sequence]
RGNLPKESVQILRDWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFIN
ARRRLLPDMLRKDGKDP
3D structure
PDB6fqp TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling.
ChainA
Resolution2.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R168 N170 L171 Q210 N217 R221 R1 N3 L4 Q43 N50 R54 PDBbind-CN: Kd=169.9nM
BS02 dna A R168 Y191 K197 I216 R219 R220 R1 Y24 K30 I49 R52 R53 PDBbind-CN: Kd=169.9nM
Gene Ontology
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6fqp, PDBe:6fqp, PDBj:6fqp
PDBsum6fqp
PubMed30060237
UniProtQ15583|TGIF1_HUMAN Homeobox protein TGIF1 (Gene Name=TGIF1)

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