Structure of PDB 6fox Chain A

Receptor sequence
>6foxA (length=449) Species: 294 (Pseudomonas fluorescens) [Search protein sequence]
RQVTIIGAGLAGTLVARLLARNGWQVNLFERRPDPRIETGARGRSINLAL
AERGAHALRLAGLEREVLAEAVMMRGRMVHVPGTPPNLQPYGRDDSEVIW
SINRDRLNRILLDGAEAAGASIHFNLGLDSVDFARQRLTLSNVSGERLEK
RFHLLIGADGCNSAVRQAMASVVDLGEHLETQPHGYKELQITPEASAQFN
LEPNALHIWPHGDYMCIALPNLDRSFTVTLFLHHQSPAAQPASPSFAQLV
DGHAARRFFQRQFPDLSPMLDSLEQDFEHHPTGKLATLRLTTWHVGGQAV
LLGDAAHPMVPFHGQGMNCALEDAVALAEHLQSAADNASALAAFTAQRQP
DALAIQAMALENYVEMSSKVASPTYLLERELGQIMAQRQPTRFIPRYSMV
TFSRLPYAQAMARGQIQEQLLKFAVANHSDLTSINLDAVEHEVTRCLPP
3D structure
PDB6fox A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.9: kynurenine 3-monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A I13 G14 G16 L17 A18 E37 R38 R39 L55 A56 R111 G134 L135 D166 G167 Y193 G310 D311 P318 G321 G323 M324 N325 I6 G7 G9 L10 A11 E30 R31 R32 L48 A49 R104 G127 L128 D159 G160 Y186 G303 D304 P311 G314 G316 M317 N318
BS02 CA A P318 G321 Q322 G323 P311 G314 Q315 G316
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004497 monooxygenase activity
GO:0004502 kynurenine 3-monooxygenase activity
GO:0016174 NAD(P)H oxidase H2O2-forming activity
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding
Biological Process
GO:0006569 tryptophan catabolic process
GO:0009435 NAD biosynthetic process
GO:0019363 pyridine nucleotide biosynthetic process
GO:0019674 NAD metabolic process
GO:0019805 quinolinate biosynthetic process
GO:0034354 'de novo' NAD biosynthetic process from tryptophan
GO:0043420 anthranilate metabolic process
GO:0070189 kynurenine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6fox, PDBe:6fox, PDBj:6fox
PDBsum6fox
PubMed31372510
UniProtQ84HF5|KMO_PSEFL Kynurenine 3-monooxygenase (Gene Name=kmo)

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