Structure of PDB 6fod Chain A

Receptor sequence
>6fodA (length=239) Species: 7955 (Danio rerio) [Search protein sequence]
HMLSDEQMQIINSLVEAHHKTYDDSYSDFVRFRPPVRRLSMLPHLADLVS
YSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEIIMLRSNQSFSLEDMS
WSCGGPDFKYCINDVTKAGHTLELLEPLVKFQVGLKKLKLHEEEHVLLMA
ICLLSPDRPGVQDHVRIEALQDRLCDVLQAYIRIQHPGGRLLYAKMIQKL
ADLRSLNEEHSKQYRSLSFQPEHSMQLTPLVLEVFGSEV
3D structure
PDB6fod Aromatic-Based Design of Highly Active and Noncalcemic Vitamin D Receptor Agonists.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I270 K274 I288 K292 E446 V447 E451 I57 K61 I75 K79 E233 V234 E238
BS02 E05 A Y175 S265 I299 R302 S303 S306 W314 C316 Y323 H333 H423 Y427 F448 Y22 S52 I86 R89 S90 S93 W101 C103 Y110 H120 H210 Y214 F235 MOAD: ic50=7.11nM
PDBbind-CN: -logKd/Ki=8.15,IC50=7.11nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:6fod, PDBe:6fod, PDBj:6fod
PDBsum6fod
PubMed29733645
UniProtQ9PTN2|VDRA_DANRE Vitamin D3 receptor A (Gene Name=vdra)

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