Structure of PDB 6foc Chain A

Receptor sequence
>6focA (length=481) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
IGTVIDAGDGIAHVEGLPSVMTQELLEFPGGVLGVALNLDEHSVGAVILG
EFEKIEEGQQVKRTGEVLSVPVGDAFLGRVVNPLGQPIDGQGDIAAETRR
ALELQAPSVVQRQSVSEPLQTGIKAIDAMTPIGRGQRQLIIGDRKTGKTA
VCVDTILNQRVRCVYVAIGQKGTTIASVKRALEEGGAMEYTTIVAAPASD
AAGFKWLAPYTGSAIGQHWMYNGKHVLIVFDDLSKQADAYRAISLLLRRP
PGREAFPGDVFYLHSRLLERCAKLSDELGGGSMTGLPIIETKANDISAFI
PTNVISITDGQCFLESDLFNQGVRPAINVGVSVSRVGGAAQIKAMKEVAG
SLRLDLSQYRELEAFAAFASDLDAASKAQLDRGARLVELLKQPQYSPLAV
EEQVVAIFLGTQGHLDSVPVEDVQRFESELLEHVKASHSDIFDGIRETKK
LSEEAEEKLVSVINEFKKGFAAAAAAAAAAA
3D structure
PDB6foc The structure of the catalytic domain of the ATP synthase fromMycobacterium smegmatisis a target for developing antitubercular drugs.
ChainA
Resolution4.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K178 Q211 K212 R376
Catalytic site (residue number reindexed from 1) K148 Q170 K171 R335
Enzyme Commision number 7.1.2.2: H(+)-transporting two-sector ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A K175 T176 G177 K178 T179 R365 Q433 Q435 K145 T146 G147 K148 T149 R324 Q392 Q394
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0032559 adenyl ribonucleotide binding
GO:0043531 ADP binding
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0006754 ATP biosynthetic process
GO:0015986 proton motive force-driven ATP synthesis
GO:0046034 ATP metabolic process
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0045259 proton-transporting ATP synthase complex
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)

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Cellular Component
External links
PDB RCSB:6foc, PDBe:6foc, PDBj:6foc
PDBsum6foc
PubMed30683723
UniProtA0R202|ATPA_MYCS2 ATP synthase subunit alpha (Gene Name=atpA)

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