Structure of PDB 6fo7 Chain A

Receptor sequence
>6fo7A (length=239) Species: 7955 (Danio rerio) [Search protein sequence]
HMLSDEQMQIINSLVEAHHKTYDDSYSDFVRFRPPVRRLSMLPHLADLVS
YSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEIIMLRSNQSFSLEDMS
WSCGGPDFKYCINDVTKAGHTLELLEPLVKFQVGLKKLKLHEEEHVLLMA
ICLLSPDRPGVQDHVRIEALQDRLCDVLQAYIRIQHPGGRLLYAKMIQKL
ADLRSLNEEHSKQYRSLSFQPEHSMQLTPLVLEVFGSEV
3D structure
PDB6fo7 Aromatic-Based Design of Highly Active and Noncalcemic Vitamin D Receptor Agonists.
ChainA
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I270 K274 I288 K292 P442 L443 E446 E451 I57 K61 I75 K79 P229 L230 E233 E238
BS02 LX3 A Y175 L258 S265 I299 R302 S303 S306 W314 C316 Y323 V328 H333 H423 Y22 L45 S52 I86 R89 S90 S93 W101 C103 Y110 V115 H120 H210 PDBbind-CN: -logKd/Ki=7.87,IC50=13.6nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:6fo7, PDBe:6fo7, PDBj:6fo7
PDBsum6fo7
PubMed29733645
UniProtQ9PTN2|VDRA_DANRE Vitamin D3 receptor A (Gene Name=vdra)

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