Structure of PDB 6fo5 Chain A

Receptor sequence
>6fo5A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB6fo5 Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach.
ChainA
Resolution0.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DZH A P82 F83 L92 L94 N140 D145 M149 P41 F42 L51 L53 N99 D104 M108 MOAD: Kd=0.19uM
PDBbind-CN: -logKd/Ki=6.72,Kd=0.19uM
BindingDB: IC50=251nM,Kd=190nM
External links
PDB RCSB:6fo5, PDBe:6fo5, PDBj:6fo5
PDBsum6fo5
PubMed29883107
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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