Structure of PDB 6fnx Chain A

Receptor sequence
>6fnxA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB6fnx Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach.
ChainA
Resolution1.19 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DYZ A W81 P82 F83 V87 N140 I146 W40 P41 F42 V46 N99 I105 MOAD: ic50=12.6uM
PDBbind-CN: -logKd/Ki=4.90,IC50=12.6uM
BindingDB: IC50=12589nM
External links
PDB RCSB:6fnx, PDBe:6fnx, PDBj:6fnx
PDBsum6fnx
PubMed29883107
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

[Back to BioLiP]