Structure of PDB 6fnu Chain A

Receptor sequence
>6fnuA (length=296) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
NLYFQSMSIRDLYHARASPFISLEFFPPKTELGTRNLMERMHRMTALDPL
FITVTWGAGGTTAEKTLTLASLAQQTLNIPVCMHLTCTNTEKAIIDDALD
RCYNAGIRNILALRGDPPIGEDWLDSPFKYAVDLVRYIKQSYGDKFCVGV
AAYPEGHCEGQDPLKDLVYLKEKVEAGADFVITQLFYDVEKFLTFEMLFR
ERISQDLPLFPGLMPINSYLLFHRAAKLSHASIPPAILSRFPPEIQSDDN
AVKSIGVDILIELIQEIYQRTSGRIKGFHFYTLNLEKAIAQIVSQS
3D structure
PDB6fnu Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.
ChainA
Resolution1.56 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S16 E18 D110 A230 H284
Catalytic site (residue number reindexed from 1) S22 E24 D116 A225 H279
Enzyme Commision number 1.5.1.20: methylenetetrahydrofolate reductase [NAD(P)H].
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A T49 W50 H78 L107 R108 G109 Y129 A130 A150 Y152 H156 D171 Y174 E177 K178 I187 T55 W56 H84 L113 R114 G115 Y130 A131 A151 Y153 H157 D166 Y169 E172 K173 I182
Gene Ontology
Molecular Function
GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity
Biological Process
GO:0006555 methionine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6fnu, PDBe:6fnu, PDBj:6fnu
PDBsum6fnu
PubMed29891918
UniProtP46151|MTHR1_YEAST Methylenetetrahydrofolate reductase 1 (Gene Name=MET12)

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