Structure of PDB 6fnt Chain A

Receptor sequence
>6fntA (length=322) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
HMALSLANYLAADSAAEALRRDVRAGLTATQKSLPPKWFYDAVGSDLFDQ
ITRLPEYYPTRTEAQILRTRSAEIISAAGADTLVELGSGTSEKTRMLLDA
MRDAELLRRFIPFDVDAGVLRSAGAAIGAEYPGIEIDAVCGDFEEHLGKI
PHVGRRLVVFLGSTIGNLTPAPRAEFLSTLADTLQPGDSLLLGTDLVKDT
GRLVRAYDDAAGVTAAFNRNVLAVVNRELSADFDLDAFEHVAKWNSDEER
IEMWLRARTAQHVRVAALDLEVDFAAGEEMLTEVSCKFRPENVVAELAEA
GLRQTHWWTDPAGDFGLSLAVR
3D structure
PDB6fnt Inhibition and Regulation of the Ergothioneine Biosynthetic Methyltransferase EgtD.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.44: L-histidine N(alpha)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AVO A Y39 F47 Y56 G161 T163 N166 Y206 E282 S284 Y40 F48 Y57 G162 T164 N167 Y207 E283 S285 MOAD: Ki=21uM
PDBbind-CN: -logKd/Ki=4.68,Ki=21uM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0052706 L-histidine N(alpha)-methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0052699 ergothioneine biosynthetic process
GO:0052704 ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide

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Molecular Function
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Biological Process
External links
PDB RCSB:6fnt, PDBe:6fnt, PDBj:6fnt
PDBsum6fnt
PubMed29658702
UniProtA0R5M8|EGTD_MYCS2 Histidine N-alpha-methyltransferase (Gene Name=egtD)

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