Structure of PDB 6fnj Chain A

Receptor sequence
>6fnjA (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]
AKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTER
QRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLR
LNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKV
SDFGLIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVMSFGERPYWDMSN
QDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQIVSALDK
MIRNPASLKIVA
3D structure
PDB6fnj NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.
ChainA
Resolution1.239 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D740 A742 R744 N745 D758 P783
Catalytic site (residue number reindexed from 1) D134 A136 R138 N139 D152 P157
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DWT A V629 A645 K647 E664 M668 I677 T693 F695 M696 Y736 S757 D758 F759 V23 A39 K41 E58 M62 I71 T87 F89 M90 Y130 S151 D152 F153 MOAD: Kd=142nM
PDBbind-CN: -logKd/Ki=6.85,Kd=142nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6fnj, PDBe:6fnj, PDBj:6fnj
PDBsum6fnj
PubMed29928781
UniProtP54760|EPHB4_HUMAN Ephrin type-B receptor 4 (Gene Name=EPHB4)

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