Structure of PDB 6fni Chain A

Receptor sequence
>6fniA (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
AKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLERQRREF
LSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQ
FTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGL
SRFIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQD
VINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQIVSALDKMI
RNPASLKIVAR
3D structure
PDB6fni NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.
ChainA
Resolution1.468 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D740 A742 R744 N745 D758 P783
Catalytic site (residue number reindexed from 1) D129 A131 R133 N134 D147 P155
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DXH A A645 E664 M668 T693 M696 Y736 L747 S757 D758 F759 F764 A39 E53 M57 T82 M85 Y125 L136 S146 D147 F148 F153 MOAD: Kd=6nM
PDBbind-CN: -logKd/Ki=8.22,Kd=6nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6fni, PDBe:6fni, PDBj:6fni
PDBsum6fni
PubMed29928781
UniProtP54760|EPHB4_HUMAN Ephrin type-B receptor 4 (Gene Name=EPHB4)

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