Structure of PDB 6fmo Chain A

Receptor sequence
>6fmoA (length=448) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
LPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIV
GDPHEHSRFFSPRNEILSPREVYTFMTPVFGEGVAYAAPYPRMREQLNFL
AEELTIAKFQNFVPAIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTAC
QCLFGEDLRKRLNARHFAQLLSKMESSLIPAAVFMPWLLRLPLPQSARCR
EARAELQKILGEIIVAREKEEASKDNNTSDLLGGLLKAVYRDGTRMSLHE
VCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQL
NYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDII
ACSPLLSHHDEEAFPNPRLWDPERDEKVDGAFIGFGAGVHKCIGQKFALL
QVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVKYTRKKK
3D structure
PDB6fmo Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51.
ChainA
Resolution3.18 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.14.154: sterol 14alpha-demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A Y116 A291 T295 L356 V359 R361 F415 H420 C422 I423 G424 Y86 A261 T265 L326 V329 R331 F385 H390 C392 I393 G394
BS02 DVE A Y103 M106 A287 A288 F290 M358 Y73 M76 A257 A258 F260 M328
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008398 sterol 14-demethylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0016126 sterol biosynthetic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fmo, PDBe:6fmo, PDBj:6fmo
PDBsum6fmo
PubMed30327430
UniProtQ7Z1V1|CP51_TRYCC Sterol 14-alpha demethylase (Gene Name=CYP51)

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