Structure of PDB 6fmf Chain A

Receptor sequence
>6fmfA (length=155) Species: 9606 (Homo sapiens) [Search protein sequence]
FKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSY
REWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITI
KEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVY
GCKIT
3D structure
PDB6fmf Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells.
ChainA
Resolution2.811 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DUE A Y297 S298 N300 W301 D320 S346 E348 T349 K351 Y353 G414 Y25 S26 N28 W29 D48 S74 E76 T77 K79 Y81 G142 PDBbind-CN: -logKd/Ki=5.88,Kd=1.32uM
BS02 TFA A S298 T299 S26 T27
External links
PDB RCSB:6fmf, PDBe:6fmf, PDBj:6fmf
PDBsum6fmf
PubMed29648813
UniProtO14786|NRP1_HUMAN Neuropilin-1 (Gene Name=NRP1)

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