Structure of PDB 6fl8 Chain A

Receptor sequence
>6fl8A (length=429) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
EVLFQGPMEMILEEKDASDWIYRGEGGANLVLAYAGSSPLFVGKVIRIQK
ARRKNSNGVVSVLTSDEQHLWRENNELISSPNKEVLEQRYVQNVIIPLLG
PKHVDAGVRVSVSKEFLECVDKKVTKQRPLWRVNAANVDTSHDSALILND
HSLFSQSGGDCISVEIKPKCGFLPTSRFIGKENMLKTSVSRFKMHQLLKL
EYIEISEESEYDPLDLFSGSKERVLEAIKALYSTPQNNFRVFLNGSLILG
GSGESTGRTSPEIGYAFEDALKGFIQSEDGHRTECFLQLVSDAVYGSGVL
DRLLEIQKLDKLDIEGAIHCYYDIINQPCPICKELSLHALPLDESLKIVK
EYLIAATAKDCSIMISFQSRNAWDSEPSGDYVSLKPTNQTFDYKVHFIDL
SLKPLKRMESYYKLDKKIISFYNRKQKAE
3D structure
PDB6fl8 A Fluorescent Probe Identifies Active Site Ligands of Inositol Pentakisphosphate 2-Kinase.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.158: inositol-pentakisphosphate 2-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TIY A G20 K168 K170 K200 N238 D368 G27 K167 K169 K199 N237 D360 MOAD: Ki=1.08uM
BS02 ADP A R16 E18 G19 A21 N22 V24 R40 N147 D148 H149 E166 M372 D407 R23 E25 G26 A28 N29 V31 R47 N149 D150 H151 E165 M364 D399
BS03 ZN A H320 C330 C333 H346 H319 C329 C332 H338
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0032942 inositol-1,4,5,6-tetrakisphosphate 2-kinase activity
GO:0035299 inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity
GO:0046872 metal ion binding
GO:0102731 inositol-1,3,4,6-tetrakisphosphate 2-kinase activity
Biological Process
GO:0010264 myo-inositol hexakisphosphate biosynthetic process
GO:0016310 phosphorylation
GO:0030643 intracellular phosphate ion homeostasis
GO:0042742 defense response to bacterium
GO:0048527 lateral root development
GO:0050832 defense response to fungus
GO:0051607 defense response to virus
GO:0055062 phosphate ion homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fl8, PDBe:6fl8, PDBj:6fl8
PDBsum6fl8
PubMed30160967
UniProtQ93YN9|IPPK_ARATH Inositol-pentakisphosphate 2-kinase (Gene Name=IPK1)

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