Structure of PDB 6fiv Chain A

Receptor sequence
>6fivA (length=112) Species: 11674 (Feline immunodeficiency virus (isolate Petaluma)) [Search protein sequence]
GTTTTLEKRPEILIFVNGYPIKFLLDTGADITILNRRDFQVKNSIENGRQ
NMIGVGGGKRGTNYINVHLEIRDENYKTQCIFGNVCVLEDNSLIVPLLGR
DNMIKFNIRLVM
3D structure
PDB6fiv Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.-
3.6.1.23: dUTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3TL A G32 A33 D34 M56 I57 G58 V59 G28 A29 D30 M52 I53 G54 V55 MOAD: Ki=8.3nM
PDBbind-CN: -logKd/Ki=8.08,Ki=8.3nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6fiv, PDBe:6fiv, PDBj:6fiv
PDBsum6fiv
PubMed10651036
UniProtP16088|POL_FIVPE Pol polyprotein (Gene Name=pol)

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