Structure of PDB 6fio Chain A

Receptor sequence
>6fioA (length=307) Species: 9606 (Homo sapiens) [Search protein sequence]
DGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKG
HPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPL
CMITDYMENGDLNQFLSAHQLEDKAAEGADPTISYPMLLHVAAQIASGMR
YLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVL
PIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIE
NAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL
AEDALNT
3D structure
PDB6fio DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome.
ChainA
Resolution1.99 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D760 R764 N765 D778
Catalytic site (residue number reindexed from 1) D161 R165 N166 D179
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DJH A L616 V624 K655 M676 I685 M704 L767 A777 D778 F779 L19 V27 K58 M79 I88 M107 L168 A178 D179 F180 MOAD: ic50=0.03uM
BindingDB: IC50=30.3nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fio, PDBe:6fio, PDBj:6fio
PDBsum6fio
PubMed30452219
UniProtQ08345|DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 (Gene Name=DDR1)

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