Structure of PDB 6fil Chain A

Receptor sequence
>6filA (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
DFPRSRLRFKEKLGEGQFGEVHLCEVDSPPLLVAVKILRPDATKNARNDF
LKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLE
DKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG
ENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASD
VWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPA
CPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNT
3D structure
PDB6fil DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome.
ChainA
Resolution1.73 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D760 R764 N765 D778
Catalytic site (residue number reindexed from 1) D141 R145 N146 D159
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D6W A V624 A653 K655 E672 M676 I685 M699 T701 M704 L767 A777 D778 F779 V21 A34 K36 E53 M57 I66 M80 T82 M85 L148 A158 D159 F160 MOAD: ic50=1.41uM
PDBbind-CN: -logKd/Ki=5.85,IC50=1.41uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6fil, PDBe:6fil, PDBj:6fil
PDBsum6fil
PubMed30452219
UniProtQ08345|DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 (Gene Name=DDR1)

[Back to BioLiP]