Structure of PDB 6fgy Chain A

Receptor sequence
>6fgyA (length=379) Species: 9606 (Homo sapiens) [Search protein sequence]
FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL
HRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRAN
IAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPN
LFSLQLCGASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEIN
GQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPD
GFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPV
EDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQ
3D structure
PDB6fgy Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors.
ChainA
Resolution1.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.23.46: memapsin 2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D9W A G59 Q60 G61 L78 D80 Y119 F156 I166 D276 G278 T280 G13 Q14 G15 L32 D34 Y73 F110 I120 D219 G221 T223 MOAD: ic50=70nM
PDBbind-CN: -logKd/Ki=7.15,IC50=70nM
BindingDB: IC50=70nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fgy, PDBe:6fgy, PDBj:6fgy
PDBsum6fgy
PubMed29764741
UniProtP56817|BACE1_HUMAN Beta-secretase 1 (Gene Name=BACE1)

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