Structure of PDB 6fgq Chain A

Receptor sequence
>6fgqA (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
QGASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKS
MWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVL
VRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHF
SEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSI
LAKLPPKGKLRSLCHVERLQIFQHLHPIV
3D structure
PDB6fgq Potent and Orally Bioavailable Inverse Agonists of ROR gamma t Resulting from Structure-Based Design.
ChainA
Resolution2.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D9N A Q286 L287 H323 R364 M365 R367 A368 F377 F378 F388 L396 I397 I400 F401 Q24 L25 H61 R102 M103 R105 A106 F115 F116 F126 L134 I135 I138 F139 MOAD: ic50=0.014uM
PDBbind-CN: -logKd/Ki=7.85,IC50=0.014uM
BindingDB: IC50=21nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fgq, PDBe:6fgq, PDBj:6fgq
PDBsum6fgq
PubMed30095900
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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