Structure of PDB 6ffs Chain A

Receptor sequence
>6ffsA (length=182) Species: 12130 (rhinovirus A2) [Search protein sequence]
GSGPEEEFGMSLIKHNSCVITTENGKFTGLGVYDRFVVVPTHADPGKEIQ
VDGITTKVIDSYDLYNKNGIKLEITVLKLDRNEKFRDIRRYIPNNEDDYP
NCNLALLANQPEPTIINVGDVVSYGNILLSGNQTARMLKYSYPTKSGYCG
GVLYKIGQVLGIHVGGNGRDGFSAMLLRSYFT
3D structure
PDB6ffs Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors.
ChainA
Resolution1.86 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H40 E71 G145 C147
Catalytic site (residue number reindexed from 1) H42 E73 G147 C149
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D8E A H40 L127 S128 N130 T142 K143 C147 V162 G163 G164 N165 F170 H42 L129 S130 N132 T144 K145 C149 V164 G165 G166 N167 F172 PDBbind-CN: -logKd/Ki=7.20,IC50=0.063uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6ffs, PDBe:6ffs, PDBj:6ffs
PDBsum6ffs
PubMed29433930
UniProtP04936|POLG_HRV2 Genome polyprotein

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