Structure of PDB 6fff Chain A

Receptor sequence
>6fffA (length=113) Species: 9606 (Homo sapiens) [Search protein sequence]
MGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKH
PMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKL
QDVFEFRYAKMPD
3D structure
PDB6fff Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain.
ChainA
Resolution1.67 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D7H A W370 P371 L383 Y386 Y428 N429 V435 M438 W28 P29 L41 Y44 Y86 N87 V93 M96 PDBbind-CN: -logKd/Ki=7.30,IC50=50.1nM
BindingDB: IC50=100nM
External links
PDB RCSB:6fff, PDBe:6fff, PDBj:6fff
PDBsum6fff
PubMed29656650
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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