Structure of PDB 6few Chain A

Receptor sequence
>6fewA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
VDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSVRKGHPLLVAVKILR
PDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGD
LNQFLSAHQLEDKAAPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATR
NCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKF
TTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYL
SRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALN
3D structure
PDB6few DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome.
ChainA
Resolution1.44 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D766 R770 N771 D784
Catalytic site (residue number reindexed from 1) D146 R150 N151 D164
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D6W A V624 A653 K655 E672 M676 I685 M699 T701 M704 L773 A783 D784 F785 V22 A45 K47 E64 M68 I77 M91 T93 M96 L153 A163 D164 F165 MOAD: ic50=1.41uM
PDBbind-CN: -logKd/Ki=5.85,IC50=1.41uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6few, PDBe:6few, PDBj:6few
PDBsum6few
PubMed30452219
UniProtQ08345|DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 (Gene Name=DDR1)

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