Structure of PDB 6fer Chain A

Receptor sequence
>6ferA (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
VAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGPVLVAVKMLRADANKNAR
NDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRH
TVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFG
MSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET
FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLS
CWRRDTKNRPSFQEIHLLLLQ
3D structure
PDB6fer DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome.
ChainA
Resolution2.87 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D757 R761 N762 D775
Catalytic site (residue number reindexed from 1) D130 R134 N135 D148
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D6Q A L616 V624 M676 I685 M699 T701 Y703 M704 F753 L764 A774 D775 F776 L17 V25 M60 I69 M83 T85 Y87 M88 F126 L137 A147 D148 F149 PDBbind-CN: -logKd/Ki=4.36,IC50=44.1uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fer, PDBe:6fer, PDBj:6fer
PDBsum6fer
PubMed30452219
UniProtQ16832|DDR2_HUMAN Discoidin domain-containing receptor 2 (Gene Name=DDR2)

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