Structure of PDB 6fek Chain A

Receptor sequence
>6fekA (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
GPLSLSVDAFKILAAPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGR
AGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGP
LLLIVEYAKYGSLRGFLRESRKVGPGPDERALTMGDLISFAWQISQGMQY
LAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDFYVKRSQGRIP
VKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLL
KTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMV
3D structure
PDB6fek A secondary RET mutation in the activation loop conferring resistance to vandetanib.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D874 R878 N879 D892
Catalytic site (residue number reindexed from 1) D160 R164 N165 D178
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADN A V738 A756 A807 L881 V39 A57 A108 L167
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6fek, PDBe:6fek, PDBj:6fek
PDBsum6fek
PubMed29434222
UniProtP07949|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)

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