Structure of PDB 6fe6 Chain A

Receptor sequence
>6fe6A (length=160) Species: 31647 (Hepatitis C virus subtype 1b) [Search protein sequence]
TGRDKNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPI
TQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGD
SRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVP
VESMETTMRA
3D structure
PDB6fe6 Solution structure of a last generation macrocyclic inhibitor. Hepatitis C virus NS3 protease complex: when S prime region occupancy is not enough to stabilize the protein conformation in the absence of NS4A.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4P2 A S42 H57 V78 D81 V132 L135 K136 G137 S139 F154 R155 A156 A157 V158 C159 S21 H36 V57 D60 V111 L114 K115 G116 S118 F133 R134 A135 A136 V137 C138
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6fe6, PDBe:6fe6, PDBj:6fe6
PDBsum6fe6
PubMed
UniProtA6N4I5

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