Structure of PDB 6fe3 Chain A

Receptor sequence
>6fe3A (length=333) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
VTAITKVEREAVLVCELPSFDVTDVEFDLFRARESTDKPLDVAAAIAYRL
LLGSGLPQKFGCSDEVLLNFILQCRKKYRNVPYHNFYHVVDVCQTIHTFL
YRGNVYEKLTELECFVLLITALVHDLDHMGLNNSFYLKTESPLGILSSAS
GNTSVLEVHHCNLAVEILSDPESDVFDGLEGAERTLAFRSMIDCVLATDM
AKHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISNVTKPFDISRQ
WAMAVTEEFYRQGDMEKERGVEVLPMFDRSKNMELAKGQIGFIDFVAAPF
FQKIVDACLQGMQWTVDRIKSNRAQWERVLETR
3D structure
PDB6fe3 TbrPDEB1 structure with inhibitor NPD-1439
ChainA
Resolution1.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D68 A M785 N825 A837 M861 Q874 G876 F877 F880 M200 N240 A252 M276 Q289 G291 F292 F295 BindingDB: Ki=407nM
BS02 ZN A H673 H709 D710 D822 H88 H124 D125 D237
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6fe3, PDBe:6fe3, PDBj:6fe3
PDBsum6fe3
PubMed
UniProtQ8WQX9

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