Structure of PDB 6fd3 Chain A

Receptor sequence
>6fd3A (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
SMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEV
AIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY
LAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNIL
LGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVD
IWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRD
FLNRCLEMDVDRRGSAKELLQHPFLKLDKPLSSLTPLIIAAKEAIKN
3D structure
PDB6fd3 Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited incis.
ChainA
Resolution1.52 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D402 K404 D406 N407 D420 P429 T440
Catalytic site (residue number reindexed from 1) D143 K145 D147 N148 D161 P170 T181
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N407 D420 N148 D161
BS02 ADP A I289 G292 S294 G295 V297 A310 K312 M357 Y359 L360 D406 L409 D420 I30 G33 S35 G36 V38 A51 K53 M98 Y100 L101 D147 L150 D161
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6fd3, PDBe:6fd3, PDBj:6fd3
PDBsum6fd3
PubMed30858169
UniProtO75914|PAK3_HUMAN Serine/threonine-protein kinase PAK 3 (Gene Name=PAK3)

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