Structure of PDB 6fad Chain A

Receptor sequence
>6fadA (length=356) Species: 9606 (Homo sapiens) [Search protein sequence]
EQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKK
FVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKIS
GVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLH
TKCRIIHTDIKPENILLSVNEQYIRRLAALVNPLEPKNAEKLKVKIADLG
NACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDY
LFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKH
ITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLR
HPWLNS
3D structure
PDB6fad Molecular Mechanism of SR Protein Kinase 1 Inhibition by the Herpes Virus Protein ICP27.
ChainA
Resolution2.801 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Q182 L550 D564 L568 E571 K604 W606 K615 Y616 Q128 L251 D265 L269 E272 K305 W307 K316 Y317
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0044024 histone H2AS1 kinase activity
GO:0106310 protein serine kinase activity
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0006338 chromatin remodeling
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0007059 chromosome segregation
GO:0008380 RNA splicing
GO:0016310 phosphorylation
GO:0030154 cell differentiation
GO:0035092 sperm DNA condensation
GO:0035556 intracellular signal transduction
GO:0045070 positive regulation of viral genome replication
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0048024 regulation of mRNA splicing, via spliceosome
GO:0050684 regulation of mRNA processing
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016363 nuclear matrix
GO:0016607 nuclear speck

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fad, PDBe:6fad, PDBj:6fad
PDBsum6fad
PubMed31641093
UniProtQ96SB4|SRPK1_HUMAN SRSF protein kinase 1 (Gene Name=SRPK1)

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